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If you take the patches out of the pouch they will not keep well. Keep the patches in the original pack until it is time to use them. You may need medical treatment if you get some of the side effects. This medicine helps most males with low testosterone levels, but it may have unwanted side effects in a few people. When applied to clean dry skin, the patch is expected to remain in place during normal activities. Your doctor will conduct regular examinations of your prostate gland during treatment with this medicine to detect unwanted side effects.
There is suggestive evidence that injection oftestosterone into some strains of female mice increases their susceptibility to hepatoma. Regularmonitoring of serum calcium concentrations is recommended in these patients. Gynecomastia may develop and persist in patients being treated withandrogens, including ANDRODERM, for hypogonadism. Edema, with or without congestive heart failure, may be a seriouscomplication in patients with preexisting cardiac, renal, or hepatic disease seeADVERSE REACTIONS.
Each patch also contains ethanol, purified water, glycerol, glyceryl monooleate, methyl laurate, carbomer copolymer (Type B), and sodium hydroxide as excipients in the drug reservoir. Androderm patches should not be cut as the reservoir contained in the patch would leak. The Androderm 5 mg/day Transdermal Patch has a 15 cm2 active surface area and contains 24.3 mg testosterone USP. Each Androderm®5 mg/day Transdermal Patch contains 24.3 milligrams of testosterone and delivers approximately 5 milligrams of testosterone over 24 hours. Each Androderm®2.5 mg/day Transdermal Patch contains 12.2 milligrams of testosterone and delivers 2.5 milligrams of testosterone over 24 hours.
Androderm is a transdermal drug delivery system consisting of a self adhesive patch surrounding a central drug reservoir of testosterone dissolved in an alcohol-based gel. Androderm®5 mg/day Transdermal Patches are elliptical ("egg-shaped") skin-toned patches with distinct heat sealed rings. If your doctor tells you to stop using this medicine or the expiry date has passed, ask your pharmacist what to do with any patches that are left over.
Call your doctor for medical advice about side effects. This medication is banned from use in athletes by most athletic organizations. Heart attacks and strokes have been reported with the use of this medication.
A side effect is an unwanted response to a medication when it is taken in normal doses. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Store patches at room temperature and protect from heat, light, and moisture. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. If you are not sure what to do after the patch falls off, contact your doctor or pharmacist for advice.
No studies were conducted in patients with hepatic impairment. No studies were conducted in patients with renal impairment. Although it is not known how much testosterone transfers into humanmilk, ANDRODERM is contraindicated in nursing women because of the potentialfor serious adverse reactions in nursing infants. If this drugis used during pregnancy, or if the patient becomes pregnant while taking thisdrug, the patient should be apprised of the potential hazard to a fetus.
Showering 3 hours after application of ANDRODERM increased Cavg by 0.5% and decreased Cmax by 0.4% respectively, as compared to not showering. Upon removal of the ANDRODERM systems, serum testosterone concentrations decrease with an apparent half-life of approximately 70 minutes. Inactivation of testosterone occurs primarily in the liver.